In case you didn't see tillerman's suggestions:
1. A great little hardware shop. Humphrey's is more oriented to contractors and never seems to have what I want. I end up going to Ace Hardware in Fall River for most things I need for jobs around the house and garden.My own list is very utilitarian at this point: a nice neighborhood grocery store and an independent book store.
2. A boating supplies shop. Like West Marine only 100% better than West Marine.
3. A fish and chip shop serving good old mushy peas. (Hey there's a pork pie shop in Fall River so why not?)
What's on your wish list?
Or is there a local business that you just can't do without?